Griffin, a Grammy and two-time Emmy victor, has made no secret of her feelings about Trump in the past.
In one image, obtained by TMZ, the 56-year-old My Life on the D-List comedian looks directly into the camera while hoisting up Trump's severed head, which is covered in dark red blood.
One of the president's sons also spoke out about the picture on Twitter.
The image (below), which shows the comedian holding up a bloodied and swollen head, were posted on photographer Tyler Shields' blog on Tuesday, along with a behind-the-scenes video explaining the concept.
Others mocked Griffin for her status, or lack thereof, among celebrities. The photo was criticized for making light of domestic abuse.
"Tyler and I are not afraid to do images that make noise", Griffin says in the video, after praising Shields as "wildly talented".