Rafael beat Swiss player Stan Wawrinka in the final to win the title for the record tenth time.
In the 19 times that Nadal has now played Wawrinka, the Spaniard has won 16, winning the match every time he won the first set. The win also propelled him above Pete Sampras to second spot in the all-time Grand Slam titles list with 15, behind great rival Roger Federer, who has 18.
The winners that punctuated the victory over Murray were in short supply, with just 19 arriving off the Wawrinka racket, as Nadal rode the momentum to claim a commanding win without being broken - his third French Open triumph without dropping a set in all seven matches.
With Jelena Ostapenko winning the women's singles title, Sunday's match between Nadal and Wawrinka wraps up the French Open and the clay court season.
In the final set, another break gave Nadal a 4-1 lead and he would confirm his date with destiny as Wawrinka netted a backhand on his second match point.
Nadal was irresistible nearly from the off on Sunday, showing the kind of form that had seen him breeze through to the final while dropping just 29 games. Addressing the press on the court, Nadal said: "I try my best in all events. but the feeling I have here is impossible to describe and you can't compare it".
"I think from the beginning from my side, for sure, I didn't play my best tennis", Wawrinka said.
"For me to be here for many years is hard to describe. Pretty sure I've lost my vehicle keys 35 times this year". Because I need to feel strong and have low, powerful legs to play well in Wimbledon.
Wawrinka, however, took positives from the tournament as he had been on the comeback trail after a first-round loss in Madrid and a second-round defeat in Monte Carlo. On clay he's just tough to play.
I'm very happy with my team, with Magnus [Norman], with Pierre [Paganini], Yannick [Fattebert].
"It's always been an honor to play against you", Wawrinka told Nadal as he addressed the crowd.
Nadal said he had not given up hope of taking back the world number one ranking that he last held in June 2014. "Today I lost the final but three weeks ago I was feeling down, I had doubts about my game", said Wawrinka.
Michael Venus became New Zealand's first Grand Slam champion since 1974 on Saturday when he partnered American Ryan Harrison to the men's doubles title.