The findings, which were presented during the 2018 Experimental Biology meeting held in San Diego, were not the first to suggest artificial sweeteners might have a negative impact on health.
Brian Hoffmann, the Lead Researcher, said that diabetes and obesity are rising regardless of the high use of artificial sweeteners.
A container holding packets of artificial sweetener.
During recent years, excessive sugar intake has been conclusively paired with obesity, diabetes, and cardiovascular disease - all of which are now solidly tied to the overconsumption of sugar.
They fed one group a diet packed with glucose and fructose (sugars) and the other, aspartame and acesulfame potassium (sweeteners).
Despite the fact "most of these sweeteners were approved well before we had the technology to perform studies like my lab is doing", Hoffman said it's only when people "chronically consume" things like artificially-sweetened drinks that people should be concerned.
Artificial sweeteners are used by many people trying to lose weight.
They wanted to understand how sugar and sweeteners impact the lining of blood vessels - the vascular endothelium - in both cell cultures and rats.
Evidence is building that zero-calorie sweeteners are more harmful than helpful when it comes to America's obesity and diabetes epidemic, with new research announced supporting a direct link between the sugar substitute and negative health effects. Three weeks later, blood samples taken from the rodents showed what researchers described as significant differences in the levels of biochemicals, fats and amino acids.
The body changes how it processes fat and receives energy from artificial sweeteners, the researchers report.
"We observed that, in moderation, your body has the machinery to handle sugar; it is when the system is overloaded over a long period of time that this machinery breaks down", explains Hoffmann.
Once again, it seems that moderation is the best course of action. In any case, new research discovers sugar substitutions can likewise cause changes that are connected with diabetes and stoutness, proposing that switching to diet soda from regular may threaten your health.
"Our stem cell-based studies indicate that low-calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose-dependent fashion", said Dr. Sabyasachi Sen, associate professor of Medicine at George Washington University.