With the 31-year-old Cavani set to be sidelined, Uruguay coach Oscar Tabarez will likely play Cristhian Stuani up front alongside Luis Suarez for the two-time world champions.
This has been his best World Cup in terms of goals scored, as he leaves with four in total, including a hat-trick in a 3-3 draw with Spain in the group stage.
Cristiano Ronaldo declined to comment on his worldwide future after bowing out of the World Cup following Portugal's 2-1 defeat by Uruguay. He also was almost given a red card when his elbowing of an opponent was reviewed on video.
"It's not the time to talk about the future when it comes to the players and coach", the Portugal captain said.
The Portuguese did not score in the knockout stage of the world Championships no goals in 514 minutes.
Bentancur is not sure how serious the injury will prove to be, but he says Cavani was positive enough during a recovery training session with the team.
"We are a very defensive team and have very good defenders", said Forlan, who scored 36 goals in 112 caps for Uruguay.
The South Americans have conceded just one goal - the joint lowest in the tournament with Brazil - in four straight wins on their way to the showdown in Nizhny Novgorod.
Portugal's Cristiano Ronaldo looks disappointed beside celebrating players of Uruguay after the round of 16 match between Uruguay and Portugal at the 2018 soccer World Cup at the Fisht Stadium in Sochi, Russia, Saturday, June 30, 2018.
Portugal's Cristiano Ronaldo helps injured Uruguay forward Edison Cavani off the field in their last 16 clash. "We know it's a special game for us, I don't know for him". "I'm very happy that Mbappe is a French citizen". It will be very hard for us. "On a post by Antonella captioned "#VamosPapi", which means "Go Daddy", people commented saying "Papi is a loser" and "I hope you will tell Messi to play a better match against Nigeria". Griezmann's performance against Argentina was overshadowed by Mbappe's exceptional display, although he opened the scoring from the spot in the first half and hit the bar from a free kick.
And against Uruguay, they managed 61 percent ball possession, played more than double the number of passes of their opponent, and with a much better pass accuracy.