Barkley had four more carries, which only resulted in four yards gained, after his big play.
Mayfield was up next and, following a three-and-out, settled in on his second series, finding Rashard Higgins with a pretty back-shoulder throw on the sideline for a 26-yard gain.
The second of those scampers - a 5-yard, red-zone dash on fourth-and-2 - set up Mayfield's 10-yard touchdown toss to David Njoku. Then, he picked up a third-and-six and a fourth-and-two, both with his legs. The rookie quarterback completed a pass on third-and-18.
Kizer went on to make 15 starts in the Browns' 0-16 season, finishing with a 53.6 completion percentage, 11 touchdown passes and 22 interceptions, ghastly numbers for the 21 century. That's unlikely, as Hue Jackson and John Dorsey have up until now been steadfast in the support of the starter, Taylor, who couldn't have been more efficient in his own Browns debut.
Mayfield made his National Football League debut against the New York Giants on Thursday, and once again was very impressive.