Barcelona ended its slump and regained the Spanish league lead but there was little to celebrate as Lionel Messi broke his right forearm and will be sidelined for three weeks.
Having been replaced by Ousmane Dembele, Messi was seen returning to the Barca dugout with his arm heavily strapped.
He had already scored, making it 2-0 with a crisp left-footed finish, to add to a stunning opener from Philippe Coutinho.
Some fans went as far as saying the Argentinean was the best player in the match despite featuring for just 18-minutes on the pitch.
Messi then got on the score-sheet on 12 minutes with a clinical finish into the bottom corner after weaving his way into the 18-yard area.
Messi fractured the radial bone in his right arm after landing awkwardly in the 26th minute of Barcelona's 4-2 win over Sevilla.
Messi, who had scored a goal five minutes earlier, suffered the injury in the 17th minute of Barcelona's 4-2 win over Sevilla on Saturday night.
Indeed, Messi isolated Sevilla centre-back Sergi Gomez in a risky position before shifting the ball to one side and finding the bottom corner with an excellent strike.
Barca coach Ernesto Valverde said, "It is clear that it is a sensitive injury".
"It was a hard end to the game for us with the goals they scored", Valverde said.
Asked about rumours that Lopetegui could be sacked, Sergio Ramos replied: 'I always said that manager changes are never good for anyone. "We have a host of forwards who can lead the games for us".